为什么选择果蝇来研究光转导？
Why Drosophila to study phototransduction?
作者信息
Pak William L
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2054, USA.
出版信息
J Neurogenet. 2010 Jul;24(2):55-66. doi: 10.3109/01677061003797302.
Abstract
This review recounts the early history of Drosophila phototransduction genetics, covering the period between approximately 1966 to 1979. Early in this period, the author felt that there was an urgent need for a new approach in phototransduction research. Through inputs from a number of colleagues, he was led to consider isolating Drosophila mutants that are defective in the electroretinogram. Thanks to the efforts of dedicated associates and technical staff, by the end of this period, he was able to accumulate a large number of such mutants. Particularly important in this effort was the use of the mutant assay protocol based on the "prolonged depolarizing afterpotential." This collection of mutants formed the basis of the subsequent intensive investigations of the Drosophila phototransduction cascade by many investigators.
摘要
这篇综述讲述了果蝇光转导遗传学的早期历史，涵盖了大约1966年至1979年这段时期。在这段时期的早期，作者认为光转导研究迫切需要一种新方法。通过许多同事的建议，他开始考虑分离在视网膜电图方面有缺陷的果蝇突变体。由于敬业的同事和技术人员的努力，到这段时期结束时，他得以积累了大量此类突变体。在这项工作中特别重要的是基于“延长去极化后电位”的突变体检测方案的使用。这些突变体的集合为许多研究人员随后对果蝇光转导级联反应的深入研究奠定了基础。
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