Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Am J Obstet Gynecol. 2010 Sep;203(3):209.e1-6. doi: 10.1016/j.ajog.2010.03.029.
The reproductive and gynecologic outcomes for women after the pregnancy complicated by open maternal-fetal surgery (OMFS) were evaluated.
The retrospective review identified 93 women with OMFS from a single institution (1996-2007). Consent and questionnaires were sent to women. Institutional review board approval was obtained from the Committee for Protection of Human Subjects.
The total return rate was 57.3%. Total pregnancies reported were 47, with 36 delivering after 20 weeks' gestation. The uterine dehiscence and rupture rates were 14% and 14%, respectively. Fetal anomalies occurred in 4 subsequent pregnancies. Normal conception occurred in 98% of subsequent pregnancies. Gynecologic issues were reported by 8 women, with infertility, abdominal pain, and ovarian and uterine factors.
The reproductive outcomes of uterine dehiscence (14%) and rupture (14%) in a subsequent pregnancy continue to be a major counseling issue for OMFS. Fertility and gynecologic factors do not appear to be increased for women undergoing OMFS.
评估伴发开放性胎儿手术（OMFS）的妊娠对女性生殖和妇科结局的影响。
本回顾性研究从一家机构中鉴定出 93 例伴发 OMFS 的女性（1996-2007 年）。向女性发送了同意书和调查问卷。获得了人体保护委员会的机构审查委员会的批准。
总回复率为 57.3%。报告的总妊娠数为 47 例，其中 36 例在 20 周后分娩。子宫破裂和子宫破裂的发生率分别为 14%和 14%。随后的 4 次妊娠中出现胎儿畸形。随后的妊娠中 98%正常受孕。8 名女性报告出现妇科问题，包括不孕、腹痛、卵巢和子宫因素。
子宫破裂（14%）和破裂（14%）的生殖结局仍然是 OMFS 的主要咨询问题。行 OMFS 的女性的生育和妇科因素似乎没有增加。
