用于生长激素治疗的笔式注射器系统的评估
Evaluation of a pen injector system for growth hormone treatment.
作者信息
Gluckman P D, Cutfield W S
机构信息
Department of Paediatrics, University of Auckland, New Zealand.
出版信息
Arch Dis Child. 1991 Jun;66(6):686-8. doi: 10.1136/adc.66.6.686.
The increasing use of human growth hormone (hGH) treatment has resulted in the introduction of a number of alternative delivery systems to conventional syringe and needle administration. We examined patients' evaluation of a new delivery system, the Kabipen (Kabi-Vitrum). We also assessed the accuracy of hGH delivery by the Kabipen. Of the 77 survey respondents 13 had used only the Kabipen, 14 the syringe only, and 50 had used both systems. Altogether 46 (92%) of those who had used both systems preferred the Kabipen. Children over 10 years were more likely to self administer hGH with the Kabipen (64%) than syringe (25%). Patient instructions, convenience of use, and comfort of use were rated better for the Kabipen than syringe. With a dose setting of 2 units the Kabipen delivered a mean (SD) of 1.997 (0.073) units with 102.5% recovery from a unit cartridge. In summary the Kabipen is an accurate device clearly preferred by the majority of hGH recipients surveyed.
人类生长激素（hGH）治疗的使用日益增加，导致了许多替代传统注射器和针头给药的递送系统的出现。我们研究了患者对一种新的递送系统——卡比笔（卡比维特鲁姆公司生产）的评价。我们还评估了卡比笔递送hGH的准确性。在77名接受调查的受访者中，13人仅使用过卡比笔，14人仅使用过注射器，50人同时使用过这两种系统。在同时使用过这两种系统的人中，共有46人（92%）更喜欢卡比笔。10岁以上的儿童使用卡比笔自行注射hGH的可能性（64%）高于使用注射器（25%）。患者对卡比笔的使用说明、使用便利性和使用舒适度的评价高于注射器。在设定剂量为2单位时，卡比笔的平均（标准差）递送量为1.997（0.073）单位，从单位药筒中的回收率为102.5%。总之，卡比笔是一种准确的装置，在接受调查的大多数hGH接受者中显然更受青睐。
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