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Inhibition of intercellular communication by airborne particulate matter.

作者信息

Heussen G A

机构信息

Department of Toxicology, Agricultural University, Wageningen, The Netherlands.

出版信息

Arch Toxicol. 1991;65(3):252-6. doi: 10.1007/BF02307317.

DOI:10.1007/BF02307317
PMID:2053852
Abstract

To investigate the inhibition of gap junction mediated intercellular communication (IC) by extracts of airborne particulate matter (APM), V79 cells were incubated with extracts of APM and subsequently microinjected with the fluorescent dye Lucifer Yellow, after which the number of fluorescent (= communicating) cells was determined. To compare inhibitory effects on IC with mutagenicity, APM was also tested in the Salmonella microsome assay. Six different extracts were tested, two outdoor extracts representing a heavily polluted and a relatively clean sample, and four indoor extracts, taken either in livingrooms with or without wood combustion in an open fire place, or in a room with or without cigarette smoking. Non-cytotoxic doses of outdoor and indoor APM inhibited IC in V79 cells in a dose- and time-dependent manner. Mutagenicity data and IC data were correlated. These results suggest that APM has tumor promoter activity in addition to mutagenic activity.

摘要

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本文引用的文献

1
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Mutagenic activity of airborne particles inside and outside homes.家庭内外空气颗粒物的致突变活性。
Environ Mutagen. 1984;6(6):861-9. doi: 10.1002/em.2860060612.
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Correlative genotoxicity studies of airborne particles in Salmonella typhimurium and cultured human lymphocytes.鼠伤寒沙门氏菌和培养的人淋巴细胞中空气颗粒物的相关遗传毒性研究。
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Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus.感染禽肉瘤病毒温度敏感突变体的细胞中连接通透性的快速可逆降低
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Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.佛波酯处理的3T3细胞中钙敏感、磷脂依赖性蛋白激酶活性的消失。
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Phorbol ester-mediated inhibition of intercellular communication in BALB/c 3T3 cells: relationship to enhancement of cell transformation.佛波酯介导的BALB/c 3T3细胞细胞间通讯抑制：与细胞转化增强的关系
Cancer Res. 1985 Jun;45(6):2681-8.
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Cancer Res. 1986 Dec;46(12 Pt 1):6180-6.