Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109, USA.
Mol Microbiol. 2010 Oct;78(1):1-4. doi: 10.1111/j.1365-2958.2010.07217.x.
Homing endonucleases have long been known as the orchestrators of intron mobility. However, the extent of their influence on the intron and its genetic and cellular environment is still being elucidated. The accompanying paper emphasizes the importance of temporal control of endonuclease expression on splicing, expression of the host gene and cellular metabolism, while it raises questions to guide future inquiry.
归巢核酸内切酶长期以来一直被认为是内含子移动的组织者。然而，它们对内含子及其遗传和细胞环境的影响程度仍在阐明之中。随附的论文强调了内切核酸酶表达的时间控制对剪接、宿主基因表达和细胞代谢的重要性，同时提出了一些问题来指导未来的研究。
