Jeon Eun-Kyoung, Cho Ah-Young, Kim Mi-Yoon, Lee Young, Seo Young-Joon, Park Jang-Kyu, Lee Jeung-Hoon
Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
Ann Dermatol. 2009 Feb;21(1):71-4. doi: 10.5021/ad.2009.21.1.71. Epub 2009 Feb 28.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vasoproliferative disease of an unknown cause involving the skin or subcutaneous tissue of the head and neck, and particularly around the ear. It predominantly affects Caucasian adults during the third and fourth decades and it very rarely occurs in children. We experienced a case of ALHE in a 2-year-old Korean boy who had a firm, pruritic, skin-colored, subcutaneous nodule on his right upper arm. The histopathological findings were compatible with ALHE and they showed prominent vascular changes with epitheloid or histiocytoid endothelial cells surrounded by inflammatory cells, including a large proportion of eosinophils. This unusual distribution of the lesion and the young age of the patient may be associated with vaccination.
嗜酸性粒细胞增多性血管淋巴样增生（ALHE）是一种病因不明的罕见良性血管增生性疾病，累及头颈部皮肤或皮下组织，尤其是耳部周围。它主要影响30至40岁的白种成年人，很少发生于儿童。我们遇到一例2岁韩国男孩患有ALHE，其右上臂有一个质地坚硬、瘙痒、肤色的皮下结节。组织病理学检查结果与ALHE相符，显示出明显的血管变化，上皮样或组织细胞样内皮细胞被炎症细胞包围，其中包括大量嗜酸性粒细胞。病变的这种不寻常分布以及患者的年轻年龄可能与疫苗接种有关。
