Kryzhanovskiĭ G N, Shandra A A, Makul'kin R F, Godlevskiĭ L S, Mazarati A M
Biull Eksp Biol Med. 1989 Jul;108(7):18-21.
It was shown in the experiments on rats, that three neuropathological syndromes develop as a result of daily subthreshold picrotoxin injections (1.25 mg/kg). Maximal expression of syndromes was different during various periods of kindling. The development of seizure syndrome was followed by prevalence of enhanced electrical activity in hippocampus; the development of "akinetic" syndrome was the same in the caudate nuclei. Data are discussed on the positions of theory of the generator, determinant and systemic mechanisms of neuropathological syndromes.
在对大鼠的实验中发现，每日注射阈下剂量的印防己毒素（1.25毫克/千克）会导致三种神经病理综合征的出现。在点燃的不同阶段，综合征的最大表现有所不同。癫痫综合征出现后，海马体中的电活动增强更为普遍；“运动不能”综合征在尾状核中的情况相同。本文讨论了神经病理综合征的发生器、决定因素和系统机制理论方面的数据。
