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肉类蛋白水解物与高血压的综述

A review of meat protein hydrolysates and hypertension.

机构信息

Department of Biochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, Japan.

出版信息

Meat Sci. 2010 Sep;86(1):110-8. doi: 10.1016/j.meatsci.2010.04.032. Epub 2010 May 31.

Abstract

We tested the hypothesis that meat is a source of peptides that are effective at preventing and reducing chronic lifestyle-related diseases (CLSRDs) such as hypertension. This analysis reflects the importance of empowering hypertensive people in quality versus quantity of life issues, and in offering nutritional treatment options rather than medical alternatives. For both hypertensive and normotensive individuals, chemically based medications may have harmful side effects. Functional food rich in antioxidant vitamins, and proteins or biologically active peptides, can lower blood pressure in persons with essential hypertension, possibly by preventing an underlying cause of the condition. Deficiency in consumption of crucial nutrients such as proteins from meat origins, along with abnormalities in carbohydrate and fat metabolism, may underlie the etiology of the clinical course of hypertension. Food derived from meat rich in nutrients may provide physiologically functional peptides, as well as improve digestion, and the metabolism of carbohydrate and fats, thus lowering blood pressure, and normalizing associated biochemical and histopathological changes. Meat was found to have value, because proteolysis of meat muscle generated a substantial number of multi-amino acid peptides that have nutrafunctional roles, and some of which have strong angiotension-converting enzyme inhibitory activity. This also demonstrates that meat proteins might lead to better nutraceutical therapy that minimizes health problems, and might aid in finding the most effective approaches for meeting the needs of all hypertension patients.

摘要

我们检验了这样一个假设,即肉类是能够有效预防和减少高血压等慢性生活方式相关疾病(CLSRD)的肽类物质的来源。这一分析反映了赋予高血压患者在生活质量的质与量方面以权力的重要性,以及提供营养治疗选择而不是医疗替代方案的重要性。对于高血压和血压正常的个体,基于化学的药物可能具有有害的副作用。富含抗氧化维生素、蛋白质或生物活性肽的功能性食品可以降低原发性高血压患者的血压,可能是通过预防该病症的潜在病因。肉类来源的蛋白质等关键营养素的摄入不足,以及碳水化合物和脂肪代谢的异常,可能是高血压临床病程的病因基础。富含营养的肉类来源的食物可能提供具有生理功能的肽,以及改善消化以及碳水化合物和脂肪的代谢,从而降低血压并使相关的生化和组织病理学变化正常化。肉类被发现具有价值,因为肉肌肉的蛋白水解产生了大量具有营养功能的多氨基酸肽,其中一些具有很强的血管紧张素转换酶抑制活性。这也表明肉类蛋白质可能导致更好的营养疗法,最大限度地减少健康问题,并有助于找到满足所有高血压患者需求的最有效方法。

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