Feigal E, Murphy E, Vranizan K, Bacchetti P, Chaisson R, Drummond J E, Blattner W, McGrath M, Greenspan J, Moss A
Department of Internal Medicine, University of California, San Diego 92103.
J Infect Dis. 1991 Jul;164(1):36-42. doi: 10.1093/infdis/164.1.36.
Serologic assays for human T cell lymphotropic virus types I and II (HTLV I/II) infection were done in 676 intravenous drug users (IVDUs) in San Francisco between 1985 and 1987: 150 in 1985, 44 in 1986, and 482 in 1987. All sera were tested by Western blot, ELISA, and p24 RIA. A total of 111 participants were seropositive in a minimum of two assays. Duration of intravenous heroin use was strongly associated with the risk of HTLV I/II seropositivity: greater than or equal to 21 years odds ratio, 6.1 (95% confidence interval [CI], 2.2-17.5), compared with less than 10 years of heroin use. Additional independent risk factors included black or Hispanic race, female sex, and the use of drugs in a shooting gallery. Coinfection of HTLV I/II and human immunodeficiency virus was less frequent than expected by chance (P less than .02). Longitudinal specimens were available in 154 participants. The age- and race-adjusted seroconversion rate was 3.4% (95% CI, 1.3-8.9) per person per year. Of the 349 homosexual men tested, none were HTLV I/II-seropositive.
1985年至1987年间，对旧金山的676名静脉吸毒者进行了人类嗜T淋巴细胞病毒I型和II型（HTLV I/II）感染的血清学检测：1985年检测150人，1986年检测44人，1987年检测482人。所有血清均通过蛋白质印迹法、酶联免疫吸附测定法和p24放射免疫测定法进行检测。共有111名参与者至少在两种检测中呈血清阳性。静脉注射海洛因的持续时间与HTLV I/II血清阳性风险密切相关：与使用海洛因少于10年相比，使用海洛因大于或等于21年的优势比为6.1（95%置信区间[CI]，2.2 - 17.5）。其他独立风险因素包括黑人或西班牙裔种族、女性以及在射击馆使用毒品。HTLV I/II与人类免疫缺陷病毒的合并感染比偶然预期的要少（P <.02）。154名参与者有纵向样本。年龄和种族调整后的血清转化率为每人每年3.4%（95%CI，1.3 - 8.9）。在接受检测的349名同性恋男性中，没有人HTLV I/II血清呈阳性。
