Moreira E D, Ribeiro T T, Swanson P, Sampaio Filho C, Melo A, Brites C, Badaró R, Toedter G, Lee H, Harrington W
Department of Medicine, Federal University of Bahia, Salvador, Brazil.
J Acquir Immune Defic Syndr (1988). 1993 Aug;6(8):959-63.
We investigated the prevalence of human T-lymphotropic virus I/II (HTLV-I/II) infection in Bahia, a state in Northeastern Brazil. Healthy individuals (n = 327) and patients (n = 337) with a variety of diseases were screened for antibodies to HTLV-I/II using an enzyme immunoassay and Western blot. The overall prevalence among healthy subjects was 1.8% (six of 327); among patients it was 18.4% (62 of 337). Patients with AIDS had the highest prevalence of HTLV-I/II infection, 22.7% (20/88), followed by randomly selected patients from an infectious disease hospital, 19.4% (25 of 129), and tuberculosis patients, 11.1% (10 of 90). Four of 14 patients with myelopathy and three of 16 patients with lymphoid leukemia or lymphoma were seropositive for HTLV-I/II. Sixty-three of 68 HTLV-I/II-positive specimens were then typed: 53 patients were HTLV-I positive, three patients were HTLV-II positive, and in seven patients the assay could not distinguish infection by HTLV-I or II. The finding among HIV-seropositive intravenous drug users in Bahia of coinfection with HTLV-I is contrasted with reports from other areas in which dual infection occurs with HTLV-II. Although high prevalence of HTLV-I infection was found in Bahia, the extent and clinical manifestations of HTLV-I/II infection in Brazil remains imprecisely defined, and further studies are needed.
我们调查了巴西东北部巴伊亚州人类嗜T淋巴细胞病毒I/II（HTLV-I/II）感染的流行情况。使用酶免疫测定法和蛋白质印迹法，对健康个体（n = 327）和患有各种疾病的患者（n = 337）进行了HTLV-I/II抗体筛查。健康受试者中的总体流行率为1.8%（327人中有6人）；患者中的流行率为18.4%（337人中有62人）。艾滋病患者中HTLV-I/II感染的流行率最高，为22.7%（88人中有20人），其次是从传染病医院随机选取的患者，为19.4%（129人中有25人），肺结核患者为11.1%（90人中有10人）。14例脊髓病患者中有4例以及16例淋巴白血病或淋巴瘤患者中有3例HTLV-I/II血清学呈阳性。然后对68份HTLV-I/II阳性标本中的63份进行了分型：53例患者HTLV-I呈阳性，3例患者HTLV-II呈阳性，7例患者的检测无法区分是HTLV-I还是HTLV-II感染。巴伊亚州HIV血清学呈阳性的静脉吸毒者中HTLV-I合并感染的情况与其他地区HTLV-II双重感染的报告形成对比。尽管在巴伊亚州发现HTLV-I感染的流行率很高，但巴西HTLV-I/II感染的范围和临床表现仍不明确，需要进一步研究。
