Department of Pathology, Hospital Universitário de Brasília, UNB Via L2 Norte, Brasília, Brazil.
Braz J Infect Dis. 2010 Mar-Apr;14(2):190-2. doi: 10.1590/s1413-86702010000200015.
Rhinoscleroma is a chronic, infectious and granulomatous disease of the respiratory tract. There is often a delay in diagnosis due to unfamiliarity with the disease and also because culture is not always positive. We report a case in a 26-year-old woman with granular mass obstructing bilateral nasal cavities and causing breathing difficulty. Histopathological examination showed characteristic Mikulicz histiocytes containing numerous Gram-negative intracellular rod-shaped bacilli consistent with the diagnosis of rhinoscleroma. The patient was treated with gemifloxacin and tetracycline and remains asymptomatic over a year follow-up period. It is important to consider rhinoscleroma in cases of chronic nasal obstruction. As culture is not always positive, histopathological examination may be crucial to the diagnosis.
类肉瘤病是一种慢性、传染性、肉芽肿性呼吸道疾病。由于对该病不熟悉，且培养结果并非总是阳性，因此常常延误诊断。我们报告了一例 26 岁女性患者，其双侧鼻腔被颗粒状肿块阻塞，导致呼吸困难。组织病理学检查显示特征性米库利茨组织细胞，其中含有大量革兰阴性细胞内杆状细菌，符合类肉瘤病的诊断。患者接受吉米沙星和四环素治疗，随访 1 年以上无症状。对于慢性鼻阻塞的病例，应考虑类肉瘤病。由于培养结果并非总是阳性，组织病理学检查对于诊断可能至关重要。
