有机氯农药与子宫内膜异位症。
Organochlorine pesticides and endometriosis.
机构信息
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA.
出版信息
Reprod Toxicol. 2010 Nov;30(3):365-9. doi: 10.1016/j.reprotox.2010.05.011. Epub 2010 May 16.
Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cm(3) of blood for toxicologic analysis and surgeons completed operative reports regarding the presence of endometriosis. Gas chromatography with electron capture was used to quantify (ng/g serum) six OCPs. Logistic regression was utilized to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for individual pesticides and groups based on chemical structure adjusting for current cigarette smoking and lipids. The highest tertile of aromatic fungicide was associated with a fivefold risk of endometriosis (aOR=5.3; 95% CI, 1.2-23.6) compared to the lowest tertile. Similar results were found for t-nonachlor and HCB. These are the first such findings in a laproscopic cohort that suggest an association between OCP exposure and endometriosis. More prospective studies are necessary to ensure temporal ordering and confirm these findings.
目前针对持久性有机氯农药（OCPs）和子宫内膜异位症的研究还很有限。本研究纳入了 100 名年龄在 18-40 岁之间的女性，她们均因腹腔镜检查而采集了 20cm³的血液用于毒理学分析，同时外科医生也完成了关于子宫内膜异位症存在情况的手术报告。采用气相色谱法和电子捕获法来定量（ng/g 血清）六种 OCPs。基于化学结构，通过调整当前吸烟和脂质情况，利用 logistic 回归来估计个体农药和基于化学结构的农药组的调整后比值比（aOR）和 95%置信区间（CI）。与最低三分位组相比，芳香族杀真菌剂的最高三分位组与子宫内膜异位症的五倍风险相关（aOR=5.3；95%CI，1.2-23.6）。对于 t-六氯环己烷和 HCB 也发现了类似的结果。这是腹腔镜队列中首次发现 OCP 暴露与子宫内膜异位症之间存在关联的此类研究。需要进行更多的前瞻性研究以确保时间顺序并证实这些发现。
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