Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago, 5841 South Maryland, MC 6026, Chicago, IL 60637, USA.
Crit Care. 2010;14(3):164. doi: 10.1186/cc9038. Epub 2010 Jun 14.
Critically ill patients requiring mechanical ventilation frequently suffer from intensive care unit delirium, a syndrome associated with numerous poor measured outcomes. The relationship between delirium, sepsis, and sedation is complex. A discussion of the recent study ('Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS [maximizing efficacy of targeted sedation and reducing neurological dysfunction] randomized controlled trial') by Pandharipande and colleagues is presented in this commentary.
需要机械通气的危重症患者经常患有 ICU 意识障碍,这是一种与许多不良测量结果相关的综合征。意识障碍、脓毒症和镇静之间的关系很复杂。本文对 Pandharipande 等人的研究(“右美托咪定与劳拉西泮对脓毒症患者结局的影响:MENDS(最大限度提高靶向镇静效果和减少神经功能障碍)随机对照试验的预先设计分析”)进行了讨论。