Kurokawa Kazuhiro, Sasaki Kazuhiro, Makita Shuichi, Yamanari Masahiro, Cense Barry, Yasuno Yoshiaki
Computational Optics Group in the University of Tsukuba, Tsukuba, Ibaraki, Japan.
Opt Express. 2010 Apr 12;18(8):8515-27. doi: 10.1364/OE.18.008515.
Adaptive optics optical coherence tomography (AO-OCT) provides three-dimensional high-isotropic-resolution retinal images in vivo. We developed AO-OCT with a 1.03-mum probing beam and demonstrated high-penetration, high-resolution retinal imaging. Axial scans are acquired with a speed of 47,000 lines/s. AO closed loop is configured with a single deformable mirror. Seven eyes of 7 normal subjects were examined. Signal enhancement was found for all subjects. A rippled interface between nerve fiber layer and ganglion cell layer, boundary between ganglion cell layer and inner plexiform layer, and chorioscleral interface were identified. Simultaneous high-resolution and high-penetration choroidal imaging may be useful for microstructural investigation of photoreceptors and glaucomatous nerve-fiber abnormalities.
自适应光学光学相干断层扫描（AO-OCT）可在体内提供三维高各向同性分辨率的视网膜图像。我们开发了一种采用1.03微米探测光束的AO-OCT，并展示了高穿透性、高分辨率的视网膜成像。轴向扫描以47000线/秒的速度采集。AO闭环配置有单个可变形镜。对7名正常受试者的7只眼睛进行了检查。所有受试者均发现信号增强。确定了神经纤维层与神经节细胞层之间的波纹状界面、神经节细胞层与内网状层之间的边界以及脉络膜巩膜界面。同时进行高分辨率和高穿透性的脉络膜成像可能有助于对光感受器和青光眼性神经纤维异常进行微观结构研究。
