用于体内人眼光感受器三维成像的自适应光学扫描激光眼底镜/光学相干断层扫描技术
Adaptive optics SLO/OCT for 3D imaging of human photoreceptors in vivo.
作者信息
Felberer Franz, Kroisamer Julia-Sophie, Baumann Bernhard, Zotter Stefan, Schmidt-Erfurth Ursula, Hitzenberger Christoph K, Pircher Michael
机构信息
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria ; Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna Austria.
出版信息
Biomed Opt Express. 2014 Jan 10;5(2):439-56. doi: 10.1364/BOE.5.000439. eCollection 2014 Feb 1.
Abstract
We present a new instrument that is capable of imaging human photoreceptors in three dimensions. To achieve high lateral resolution, the system incorporates an adaptive optics system. The high axial resolution is achieved through the implementation of optical coherence tomography (OCT). The instrument records simultaneously both, scanning laser ophthalmoscope (SLO) and OCT en-face images, with a pixel to pixel correspondence. The information provided by the SLO is used to correct for transverse eye motion in post-processing. In order to correct for axial eye motion, the instrument is equipped with a high speed axial eye tracker. In vivo images of foveal cones as well as images recorded at an eccentricity from the fovea showing cones and rods are presented.
摘要
我们展示了一种能够对人类光感受器进行三维成像的新仪器。为了实现高横向分辨率，该系统集成了自适应光学系统。通过实施光学相干断层扫描（OCT）实现了高轴向分辨率。该仪器同时记录扫描激光检眼镜（SLO）和OCT正面图像，且像素之间具有对应关系。SLO提供的信息用于在后期处理中校正横向眼球运动。为了校正轴向眼球运动，该仪器配备了高速轴向眼球追踪器。展示了中央凹视锥细胞的体内图像以及在离中央凹一定偏心度处记录的显示视锥细胞和视杆细胞的图像。
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