Kurono Y, Shimamura K, Shigemi H, Mogi G
Department of Otolaryngology, Medical College of Oita, Japan.
Ann Otol Rhinol Laryngol. 1991 Jun;100(6):455-8. doi: 10.1177/000348949110000605.
The role of secretory immunoglobulin (Ig) A in nasopharyngeal secretions in the adherence of Streptococcus pneumoniae and Hemophilus influenzae to nasopharyngeal epithelial cells was investigated in vitro. The adherence was remarkably reduced by treating bacteria with nasopharyngeal secretions, and the antiadhesive activity was significantly greater in nasopharyngeal secretions having secretory IgA antibody activity against bacteria than in those having no activity. Noticeable changes were not observed in the antiadhesive activity caused by absorption of IgG from nasopharyngeal secretions. Results suggest that secretory IgA in nasopharyngeal secretions is related to bacterial adherence and adds to the prevention of nasopharyngeal infections.
体外研究了分泌型免疫球蛋白（Ig）A在鼻咽分泌物中对肺炎链球菌和流感嗜血杆菌黏附于鼻咽上皮细胞的作用。用鼻咽分泌物处理细菌后，黏附显著减少，并且具有针对细菌的分泌型IgA抗体活性的鼻咽分泌物中的抗黏附活性明显高于无活性的鼻咽分泌物。从鼻咽分泌物中吸收IgG后，未观察到抗黏附活性有明显变化。结果表明，鼻咽分泌物中的分泌型IgA与细菌黏附有关，并有助于预防鼻咽感染。
