Department of Tropical Hygiene, Department of Clinical Tropical Medicine, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Am J Trop Med Hyg. 2010 Jul;83(1):51-5. doi: 10.4269/ajtmh.2010.09-0621.
Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine. Thirty patients received IV-ibuprofen 400 mg and 30 received placebo every 6 hours for 72 hours. Reduction in the area above 37.0 degrees C versus time curve was significantly greater for IV-ibuprofen than for placebo during the first 72 hours after first administration. No patients developed severe malaria; parasite clearance was delayed in the patients whose fevers were controlled by IV-ibuprofen (median 37.3 hours versus 23.7 hours in the placebo group [P = 0.0024]). This difference did not appear to be clinically important Adverse events, none considered severe, occurred equally in both groups. IV-ibuprofen was effective and well tolerated in reducing fever in febrile inpatients with malaria.
由于一些发热患者无法吞咽或保留口服退烧药，我们进行了一项双盲、安慰剂对照试验，对因急性无并发症恶性疟原虫疟疾而发热并接受青蒿琥酯加甲氟喹口服治疗的住院成人患者给予静脉用布洛芬（IV-ibuprofen）。30 名患者每 6 小时接受 IV-ibuprofen 400mg，30 名患者接受安慰剂，共 72 小时。首次给药后前 72 小时，IV-ibuprofen 组与安慰剂组相比，37.0°C 以上面积相对于时间曲线的下降显著更大。没有患者发生严重疟疾；接受 IV-ibuprofen 退热的患者寄生虫清除时间延迟（中位数 IV-ibuprofen 组为 37.3 小时，安慰剂组为 23.7 小时[P=0.0024]）。这种差异似乎没有临床意义。两组患者的不良事件发生率相等，均无严重不良事件。静脉用布洛芬可有效且耐受良好，可降低疟疾发热住院患者的体温。
