Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, 12700 E. 19th Avenue, Research 2, C281, Aurora, CO 80045, USA.
J Am Soc Nephrol. 2010 Sep;21(9):1543-9. doi: 10.1681/ASN.2009111111. Epub 2010 Jul 1.
The recent increase in fructose consumption in industrialized nations mirrors the rise in the prevalence of hypertension, but epidemiologic studies have inconsistently linked these observations. We investigated whether increased fructose intake from added sugars associates with an increased risk for higher BP levels in US adults without a history of hypertension. We conducted a cross-sectional analysis using the data collected from the National Health and Nutrition Examination Survey (NHANES 2003 to 2006) involving 4528 adults without a history of hypertension. Median fructose intake was 74 g/d, corresponding to 2.5 sugary soft drinks each day. After adjustment for demographics; comorbidities; physical activity; total kilocalorie intake; and dietary confounders such as total carbohydrate, alcohol, salt, and vitamin C intake, an increased fructose intake of > or =74 g/d independently and significantly associated with higher odds of elevated BP levels: It led to a 26, 30, and 77% higher risk for BP cutoffs of > or =135/85, > or =140/90, and > or =160/100 mmHg, respectively. These results suggest that high fructose intake, in the form of added sugar, independently associates with higher BP levels among US adults without a history of hypertension.
最近，工业化国家果糖摄入量的增加与高血压患病率的上升相吻合，但流行病学研究并未一致表明这些观察结果之间存在关联。我们调查了美国成年人中，是否摄入更多来自添加糖的果糖会增加血压升高的风险，这些成年人之前没有高血压病史。我们利用 2003 至 2006 年全国健康和营养调查（NHANES）的数据进行了一项横断面分析，共涉及 4528 名没有高血压病史的成年人。中位数果糖摄入量为 74 克/天，相当于每天饮用 2.5 份含糖软饮料。调整人口统计学因素；合并症；身体活动；总热量摄入；以及总碳水化合物、酒精、盐和维生素 C 等饮食混杂因素的摄入量后，>或=74 克/天的果糖摄入量增加与更高的血压水平几率独立且显著相关：这导致血压切点>或=135/85、>或=140/90 和>或=160/100mmHg 的几率分别升高 26%、30%和 77%。这些结果表明，美国成年人中，之前没有高血压病史，摄入更多的添加糖形式的果糖会独立增加血压水平。
