Agarwal Vishal, Das Sambit, Kapoor Nitin, Prusty Binod, Das Bijay
Endocrinology, Diabetes and Metabolism, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, IND.
Cureus. 2024 Nov 21;16(11):e74143. doi: 10.7759/cureus.74143. eCollection 2024 Nov.
With the increasing intake of dietary fructose, primarily from sucrose and sweetened beverages, metabolic illnesses such as type 2 diabetes mellitus, hypertension, fatty liver disease, dyslipidemia, and hyperuricemia have become more prevalent worldwide, and there is also growing concern about the development of malignancies. These negative health impacts have been validated in various meta-analyses and randomized controlled trials. In contrast, the naturally occurring fructose found in fruits and vegetables contains only a minimal amount of fructose and, when consumed in moderation, may be a healthier choice. This review focuses on the biology of fructose, including its dietary sources, the physiology of its metabolism, and the pathological basis of various disorders related to high dietary fructose intake.
随着主要来自蔗糖和含糖饮料的膳食果糖摄入量增加，2型糖尿病、高血压、脂肪肝疾病、血脂异常和高尿酸血症等代谢性疾病在全球范围内变得更加普遍，人们也越来越关注恶性肿瘤的发生。这些负面健康影响已在各种荟萃分析和随机对照试验中得到证实。相比之下，水果和蔬菜中天然存在的果糖仅含有极少量果糖，适量食用可能是更健康的选择。本综述重点关注果糖的生物学特性，包括其膳食来源、代谢生理学以及与高膳食果糖摄入相关的各种疾病的病理基础。
