双能X线吸收测定法（DEXA）骨密度仪的体外可比性

In vitro comparability of dual energy X-ray absorptiometry (DEXA) bone densitometers.

作者信息

Rencken M L, Murano R, Drinkwater B L, Chesnut C H

机构信息

University of Washington Medical Center, Osteoporosis Research Center, Seattle 98195.

出版信息

Calcif Tissue Int. 1991 Apr;48(4):245-8. doi: 10.1007/BF02556375.

DOI:10.1007/BF02556375

PMID:2059876

Abstract

Six Hologic QDR-1000 DEXA bone densitometers at different centers across the USA were compared to determine the intermachine variability. Nine scans in succession were acquired on each machine using a single anthropomorphic lumbar spine phantom (manufactured by Hologic). Values for BMC, area, and BMD were recorded for each measurement. Means, standard deviations (SD), and coefficients of variation (CV) were calculated for each machine. All the CVs (BMC, area, BMD) were less than 1% (range 0.3%-0.6%). The CV of the means at the six sites were 0.4%, 0.6%, and 0.5% for BMC, area, and BMD, respectively. Although several significant differences for BMC, area, and BMD were noted by ANOVA between machines at different sites, the difference between the highest and lowest means of the individual machines was only 1.1%, 1.31%, and 1.07% for BMC, area, and BMD. The small variations between the DEXA systems are encouraging for researchers involved in multicenter trials in which data are pooled.

摘要

对美国不同中心的六台Hologic QDR - 1000双能X线骨密度仪进行比较，以确定仪器间的变异性。使用单个仿真腰椎模型（由Hologic制造）在每台仪器上连续进行九次扫描。记录每次测量的骨矿物质含量（BMC）、面积和骨密度（BMD）值。计算每台仪器的平均值、标准差（SD）和变异系数（CV）。所有的变异系数（BMC、面积、BMD）均小于1%（范围为0.3% - 0.6%）。六个测量点的平均值的变异系数，BMC、面积和BMD分别为0.4%、0.6%和0.5%。尽管通过方差分析（ANOVA）发现不同测量点的仪器在BMC、面积和BMD方面存在一些显著差异，但各仪器最高和最低平均值之间的差异，BMC、面积和BMD分别仅为1.1%、1.31%和1.07%。DEXA系统之间的微小差异对于参与数据汇总的多中心试验的研究人员来说是令人鼓舞的。