多能性的并行门户：干细胞和发育中的开放染色质。
Parallel gateways to pluripotency: open chromatin in stem cells and development.
机构信息
Departments of Ob/Gyn and Pathology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, San Francisco, CA 94143-0525, USA.
出版信息
Curr Opin Genet Dev. 2010 Oct;20(5):492-9. doi: 10.1016/j.gde.2010.06.002. Epub 2010 Jul 2.
Open chromatin is a hallmark of pluripotent stem cells, but the underlying molecular mechanisms are only beginning to be unraveled. In this review we highlight recent studies that employ embryonic stem cells and induced pluripotent stem cells to investigate the regulation of open chromatin and its role in the maintenance and acquisition of pluripotency in vitro. We suggest that findings from in vitro studies using pluripotent stem cells are predictive of in vivo processes of epigenetic regulation of pluripotency, specifically in the development of the zygote and primordial germ cells. The combination of in vitro and in vivo approaches is expected to provide a comprehensive understanding of the epigenetic regulation of pluripotency and reprograming.
开放染色质是多能干细胞的一个标志，但潜在的分子机制才刚刚开始被揭示。在这篇综述中，我们强调了最近的研究，这些研究利用胚胎干细胞和诱导多能干细胞来研究开放染色质的调节及其在体外维持和获得多能性中的作用。我们认为，使用多能干细胞进行的体外研究结果可预测多能性的胚胎表观遗传调控的体内过程，特别是在合子和原始生殖细胞的发育过程中。体外和体内方法的结合有望提供对多能性和重编程的表观遗传调控的全面理解。
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