Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Fitoterapia. 2010 Dec;81(8):1003-5. doi: 10.1016/j.fitote.2010.06.017. Epub 2010 Jun 28.
Two new amide alkaloids were isolated from the alkaloidal fraction of Datura metel L. Their structures were elucidated as (E)-methyl 4-(3-(4-hydroxyphenyl)-N-methylacrylamido) butanoate and 6,7-dimethyl-1-D-ribityl-quinoxaline-2,3(1H,4H)-dione-5'-O-β-D-glucopyranoside on the basis of spectroscopic methods including HRESIMS, 1D and 2D NMR. Tropane alkaloids have for a long time been considered as characteristic ingredients of D. metel. However, the presence of amide alkaloids in D. metel was reported for the first time in this study.
从曼陀罗的生物碱部分分离得到两种新的酰胺生物碱。根据包括高分辨质谱（HRESIMS）、1D 和 2D NMR 在内的光谱方法，确定它们的结构分别为（E）-甲基 4-(3-(4-羟基苯基）-N-甲基丙烯酰胺基）丁酸酯和 6,7-二甲基-1-D-核糖基喹喔啉-2,3(1H,4H)-二酮-5'-O-β-D-吡喃葡萄糖苷。莨菪烷生物碱长期以来一直被认为是曼陀罗的特征成分。然而，酰胺生物碱在曼陀罗中的存在在本研究中是首次报道。
