La Corte R, Potena A, Bajocchi G, Fabbri L, Trotta F
Division of Rheumatology, Ospedale S. Anna, Ferrara, Italy.
Clin Exp Rheumatol. 1991 Mar-Apr;9(2):125-30.
Thirty-six patients with primary Sjögren's syndrome (pSS) and 60 healthy volunteers underwent provocative bronchial testing with aerosolized dosed methacholine. On the average, pulmonary functions tests performed before bronchial testing were normal. However, 18/36 patients (50%) had bronchial hyper-responsiveness (BH), an incidence higher that that found in our control population (6.6%). No difference between BH and normally responsive patients was found in the duration of disease, immunological abnormalities or symptoms, and only the FEF50 was significantly lower in the BH group. It is therefore hypothesized that in pSS bronchial hyper-responsiveness may be due to lymphocytic inflammation and an alteration in secretion secondary to gland damage.
36例原发性干燥综合征（pSS）患者和60名健康志愿者接受了雾化定量乙酰甲胆碱激发支气管试验。平均而言，支气管试验前进行的肺功能测试正常。然而，36例患者中有18例（50%）存在支气管高反应性（BH），其发生率高于我们的对照组人群（6.6%）。在疾病持续时间、免疫异常或症状方面，BH患者与反应正常的患者之间未发现差异，且仅BH组的用力呼气流量50%（FEF50）显著降低。因此推测，在pSS中，支气管高反应性可能是由于淋巴细胞炎症以及腺体损伤继发的分泌改变所致。
