Potena A, La Corte R, Fabbri L M, Papi A, Trotta F, Ciaccia A
Dept of Medicine, S. Anna Hospital, Ferrara, Italy.
Eur Respir J. 1990 May;3(5):548-53.
We examined one group of 33 patients with primary Sjögren's syndrome, one group of 17 patients with secondary Sjögren's syndrome, i.e. associated with other connective tissue diseases, and one group of 14 patients with connective tissue diseases but without Sjögren's syndrome. In each patient we obtained chest radiographs and measured lung volumes, carbon monoxide diffusing capacity and airway responsiveness to methacholine. We observed no difference in chest radiograph abnormalities, in lung volumes and in carbon monoxide diffusing capacity among the three groups. However, we found a slight but significant increase of bronchial responsiveness in patients with primary and secondary Sjögren's syndrome compared with patients with connective tissue disorders but without Sjögren's syndrome. Thus PD20FEV1 methacholine was 1.07 mg (1.2) (geometric mean and GSEM) in primary Sjögren's syndrome, 0.91 mg (1.4) in secondary Sjögren's syndrome (NS), and 2.24 mg (1.09) in patients with connective tissue diseases but without Sjögren's syndrome (t = 2.59 and t = 2.8, both p less than 0.05, vs primary and secondary Sjögren's syndrome, respectively). These results show that some patients with Sjögren's syndrome have mild bronchial hyperresponsiveness, which may be related to the specific airway abnormalities of this disease.
我们研究了一组33例原发性干燥综合征患者、一组17例继发性干燥综合征患者（即与其他结缔组织病相关）以及一组14例患有结缔组织病但无干燥综合征的患者。我们为每位患者拍摄了胸部X光片，并测量了肺容积、一氧化碳弥散能力和气道对乙酰甲胆碱的反应性。我们观察到三组患者在胸部X光片异常、肺容积和一氧化碳弥散能力方面没有差异。然而，我们发现原发性和继发性干燥综合征患者的支气管反应性相较于患有结缔组织病但无干燥综合征的患者有轻微但显著的增加。因此，原发性干燥综合征患者的乙酰甲胆碱PD20FEV1为1.07毫克（1.2）（几何均值和几何标准差），继发性干燥综合征患者为0.91毫克（1.4）（无显著性差异），患有结缔组织病但无干燥综合征的患者为2.24毫克（1.09）（t = 2.59和t = 2.8，分别与原发性和继发性干燥综合征相比，p均小于0.05）。这些结果表明，一些干燥综合征患者存在轻度支气管高反应性，这可能与该疾病特定的气道异常有关。
