Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Open Vet J. 2023 Jul;13(7):942-947. doi: 10.5455/OVJ.2023.v13.i7.14. Epub 2023 Jul 31.
The anti-epileptic effects of docosahexaenoic acid (DHA) in dogs and humans remain controversial. The dosage and efficacy of DHA were various in the previous reports.
The effects of high-dose DHA supplementation as add-on therapy for idiopathic epilepsy in dogs were evaluated.
An open-label clinical trial was designed in this pilot study. Six dogs (median age: 6 years) with idiopathic epilepsy were included. All the patients were diagnosed with idiopathic epilepsy using magnetic MRI and cerebrospinal fluid examination (median: 2.0 years before the trial). They had 5-45 seizures and/or auras (median: 9.0) in the month before starting DHA supplementation. DHA was adjunctively administered at doses of 69-166 mg/kg/day without changing other prescriptions.
Four of the six patients completed the 6-month observation period. All the patients showed a decrease in seizure frequency of 50% or more within 2-3 months after the start of the administration, and three patients decreased to a frequency of 0-1 per month after 5-6 months. No clear adverse events were observed in the general condition or blood test results in any patients.
Although the sample size was small and the study was not a randomized controlled trial, the data suggest that add-on supplementation of DHA could be useful in reducing the frequency of seizures in canine idiopathic epilepsy.
二十二碳六烯酸（DHA）在犬和人类中的抗癫痫作用仍存在争议。先前的报告中 DHA 的剂量和疗效各不相同。
评估高剂量 DHA 补充作为犬特发性癫痫附加治疗的效果。
本研究设计为开放标签临床试验。纳入 6 只（中位年龄：6 岁）特发性癫痫犬。所有患者均通过磁共振成像和脑脊液检查诊断为特发性癫痫（试验前中位时间：2.0 年）。在开始 DHA 补充前 1 个月，他们有 5-45 次发作和/或先兆（中位：9.0 次）。DHA 以 69-166mg/kg/天的剂量辅助给药，同时不改变其他处方。
6 名患者中有 4 名完成了 6 个月的观察期。所有患者在开始给药后 2-3 个月内癫痫发作频率降低 50%或更多，3 名患者在 5-6 个月后降低至每月 0-1 次。在任何患者的一般情况或血液检查结果中均未观察到明显的不良反应。
尽管样本量较小且研究不是随机对照试验，但数据表明 DHA 附加补充可能有助于减少犬特发性癫痫的发作频率。
