State Key Lab of Urban Water Resource and Environment & the Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080, PR China ; State Key Lab of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Beilstein J Org Chem. 2012;8:1884-9. doi: 10.3762/bjoc.8.217. Epub 2012 Nov 5.
A new selaginellin named selaginellin O (1), along with three other known selaginellins (2-4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4'-hydroxy-4-formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity.
从卷柏（Beauv.）中分离得到一种新的卷柏素 O（1），以及另外三种已知的卷柏素（2-4）。基于光谱分析，确定了卷柏素 O 的结构为 4-[(4'-羟基-4-甲酰基-3-((4-羟基苯基)乙炔基)联苯-2-基)(4-羟基苯基)亚甲基]环己-2,5-二烯-1-酮。化合物 1、2 和 3 对培养的 HeLa 细胞（人宫颈癌细胞）表现出明显的细胞毒性活性，同时还具有显著的抗氧化活性。
