Legrand Philippe, Rioux Vincent
Laboratoire de Biochimie-Nutrition Humaine, Agrocampus Rennes, INRA USC 2012, 65 rue de Saint-Brieuc, CS 84215, Rennes Cedex, France.
Lipids. 2010 Oct;45(10):941-6. doi: 10.1007/s11745-010-3444-x. Epub 2010 Jul 13.
This review summarizes recent findings on the metabolism and biological functions of saturated fatty acids (SFA). Some of these findings show that SFA may have important and specific roles in the cells. Elucidated biochemical mechanisms like protein acylation (N-myristoylation, S-palmitoylation) and regulation of gene transcription are presented. In terms of physiology, SFA are involved for instance in lipogenesis, fat deposition, polyunsaturated fatty acids bioavailability and apoptosis. The variety of their functions demonstrates that SFA should no longer be considered as a single group.
本综述总结了关于饱和脂肪酸（SFA）代谢和生物学功能的最新研究结果。其中一些结果表明，SFA可能在细胞中具有重要且特定的作用。文中介绍了已阐明的生化机制，如蛋白质酰化（N-肉豆蔻酰化、S-棕榈酰化）和基因转录调控。在生理学方面，SFA参与例如脂肪生成、脂肪沉积、多不饱和脂肪酸的生物利用度和细胞凋亡等过程。其功能的多样性表明，SFA不应再被视为单一的类别。
