细胞衰老预测转移性结直肠癌的治疗结果。
Cellular senescence predicts treatment outcome in metastasised colorectal cancer.
机构信息
Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum der Charité - MKFZ, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
出版信息
Br J Cancer. 2010 Aug 10;103(4):505-9. doi: 10.1038/sj.bjc.6605784. Epub 2010 Jul 13.
BACKGROUND
Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown.
METHODS
A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis.
RESULTS
5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044).
CONCLUSION
Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed.
背景
细胞衰老（cellular senescence）是一种细胞周期的终止，它是对激活的致癌基因和 DNA 损伤化疗的反应。在诊断时，癌细胞衰老是否可能对治疗结果具有预测性尚不清楚。
方法
开发了一个衰老指数（SI），并用于回顾性分析 30 例 UICC Ⅳ期结直肠癌（CRC）患者的治疗结果与其诊断时的 SI 之间的相关性。
结果
氟尿嘧啶/亚叶酸治疗的 CRC 患者，在治疗前 SI 阳性肿瘤时，无进展生存期显著延长（中位数 12.0 个月 vs 6.0 个月；P=0.044）。
结论
在转移性 CRC 中，癌细胞衰老可预测治疗结果。需要对更大的患者队列进行前瞻性分析。
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