The Research Institute of Cardiovascular Disease, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Nanoscale Res Lett. 2009 Aug 21;4(12):1428-33. doi: 10.1007/s11671-009-9415-6.
A facile, rapid, solution-phase method of detecting human cardiac troponin I for sensing myocardial damage has been described using gold nanorods-based biosensors. The sensing is demonstrated by the distinct change of the longitudinal surface plasmon resonance wavelength of the gold nanorods to specific antibody-antigen binding events. For a higher sensitivity, the aspect ratio of gold nanorods is increased up to ca 5.5 by simply adding small amount of HCl in seed-mediated growth solution. Experimental results show that the detecting limit of the present method is 10 ng/mL. Contrast tests reveal that these gold nanorods-based plasmonic biosensors hold much higher sensitivity than that of conventionally spherical gold nanoparticles.
一种基于金纳米棒的生物传感器，通过检测金纳米棒的纵向表面等离激元共振波长的明显变化，实现了对心肌损伤进行感测的人心肌肌钙蛋白 I 的简便、快速、溶液相检测方法。为了提高灵敏度，通过在种子介导的生长溶液中简单添加少量 HCl，将金纳米棒的纵横比增加到约 5.5。实验结果表明，本方法的检测限为 10ng/ml。对比实验表明，与传统的球形金纳米粒子相比，这些基于金纳米棒的等离子体生物传感器具有更高的灵敏度。
Zotero 插件
