Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
BMC Endocr Disord. 2010 Jul 23;10:13. doi: 10.1186/1472-6823-10-13.
Cause-specific mortality is a commonly used endpoint of clinical trials or prospective studies. However, it is sometimes difficult for physician to determine the underlying-cause-of-death (UCD), especially for diabetic patients coexisted with cardiovascular diseases (CVD). The aim of this survey was to examine whether internists with different specialties have different opinions on the reporting of diabetes as the UCD.
A total of 549 physicians completed the questionnaire in Taiwan, which comprised seven hypothetical case scenarios, each indicating a different level of contribution of diabetes in initiating the chain of events leading to death.
As a whole, endocrinologists were more likely than cardiologists and nephrologists to report diabetes as the UCD. The differences were more prominent when the diabetic patient had a coexisting CVD. In scenario 3 (a diabetic patient with hypertension who died from acute myocardial infarction), the percentage was 56% in endocrinologists, which was significantly higher than in cardiologists (42%) and nephrologists (41%). In scenario 4 (a diabetic patient with hypertension who died from cerebrovascular infarction), the percentage was 45% in endocrinologists, and only 31% in cardiologists and 36% in nephrologists.
Internists of different sub-specialties do have different opinions on the reporting of diabetes as the UCD, especially when the diabetic patient has a coexisting CVD.
特定原因死亡率是临床试验或前瞻性研究中常用的终点。然而,有时医生很难确定根本死因(UCD),尤其是对于患有心血管疾病(CVD)的糖尿病患者。本研究旨在探讨不同专业的内科医生对将糖尿病报告为 UCD 的看法是否存在差异。
在台湾,共有 549 名医生完成了这项问卷调查,其中包括七个假设病例场景,每个场景都表明糖尿病在引发导致死亡的事件链中的不同程度的贡献。
总体而言,内分泌科医生比心脏病专家和肾病专家更有可能将糖尿病报告为 UCD。当糖尿病患者同时患有 CVD 时,这种差异更为明显。在场景 3(患有高血压的糖尿病患者死于急性心肌梗死)中,内分泌科医生的比例为 56%,明显高于心脏病专家(42%)和肾病专家(41%)。在场景 4(患有高血压的糖尿病患者死于脑血管梗死)中,内分泌科医生的比例为 45%,而心脏病专家和肾病专家的比例分别为 31%和 36%。
不同亚专业的内科医生对将糖尿病报告为 UCD 的看法确实存在差异,尤其是当糖尿病患者同时患有 CVD 时。