Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata-CONICET, Casilla de Correo 16, Sucursal 4, (1900) La Plata, Argentina.
J Colloid Interface Sci. 2010 Oct 15;350(2):402-8. doi: 10.1016/j.jcis.2010.06.052. Epub 2010 Jun 25.
Titanium is a corrosion-resistant and biocompatible material widely used in medical and dental implants. Titanium surfaces, however, are prone to bacterial colonization that could lead to infection, inflammation, and finally to implant failure. Silver nanoparticles (AgNPs) have demonstrated an excellent performance as biocides, and thus their integration to titanium surfaces is an attractive strategy to decrease the risk of implant failure. In this work a simple and efficient method is described to modify Ti/TiO(2) surfaces with citrate-capped AgNPs. These nanoparticles spontaneously adsorb on Ti/TiO(2), forming nanometer-sized aggregates consisting of individual AgNPs that homogeneously cover the surface. The modified AgNP-Ti/TiO(2) surface exhibits a good resistance to colonization by Pseudomonas aeruginosa, a model system for biofilm formation.
钛是一种耐腐蚀、生物相容性好的材料，广泛应用于医疗和牙科植入物。然而，钛表面容易被细菌定植，从而导致感染、炎症，最终导致植入物失败。银纳米粒子（AgNPs）作为杀菌剂表现出优异的性能，因此将其整合到钛表面是降低植入物失败风险的一种有吸引力的策略。在这项工作中，描述了一种简单有效的方法，即用柠檬酸根封端的 AgNPs 修饰 Ti/TiO(2)表面。这些纳米粒子自发地吸附在 Ti/TiO(2)上，形成由单个 AgNPs 组成的纳米级聚集体，均匀覆盖表面。修饰后的 AgNP-Ti/TiO(2)表面对铜绿假单胞菌的定植具有良好的抵抗力，铜绿假单胞菌是生物膜形成的模型系统。
