Giovinco Nicholas A, Bui Trung D, Fisher Timothy, Mills Joseph L, Armstrong David G
Southern Arizona Limb Salvage Alliance, University of Arizona College of Medicine, 1501 N Campbell Ave, Tucson, AZ 85724, USA.
Eplasty. 2010 Jan 8;10:e9.
Although the use of negative pressure wound therapy (NPWT) is broadly efficacious, it may foster some potentially adverse complications. This is particularly true in patients with diabetes who have a wound colonized with aerobic organisms. Traditional antiseptics have been proven useful to combat such bacteria but require removal of some NPWT devices to be effective.
In this article, we describe a method of "wound chemotherapy" by combining NPWT and a continuous infusion of Dakins' 0.5% solution either as a standardized technique in one device (ITI Sved) or as a modification of standard technique in another (KCI VAC) NPWT device. The twin goals of both techniques are to effectively reduce bacterial burden and to promote progressive wound healing.
We present several representative case examples of our provisional experience with continuous streaming therapy through 2 foam-based negative pressure devices.
Wound chemotherapy was successfully applied to patients with diabetes, without adverse reactions, complications, or recolonization during the course of treatment. We believe this to be a promising method to derive the benefits of NPWT without the frequent adverse sequela of wound colonization.
尽管负压伤口治疗（NPWT）的应用具有广泛的疗效，但它可能会引发一些潜在的不良并发症。对于伤口被需氧菌定植的糖尿病患者而言，情况尤其如此。传统的防腐剂已被证明对对抗此类细菌有用，但需要移除一些NPWT装置才能有效。
在本文中，我们描述了一种“伤口化疗”方法，即将NPWT与持续输注0.5%达金氏溶液相结合，这一方法可作为一种标准化技术应用于一种装置（ITI Sved），或作为另一种（KCI VAC）NPWT装置标准技术的一种改良。这两种技术的双重目标是有效减轻细菌负荷并促进伤口逐步愈合。
我们展示了通过两种基于泡沫的负压装置进行持续引流治疗的初步经验的几个代表性病例。
伤口化疗成功应用于糖尿病患者，在治疗过程中未出现不良反应、并发症或再定植情况。我们认为这是一种有前景的方法，可在不频繁出现伤口定植不良后果的情况下获得NPWT的益处。
