Divison of Cardiology, Department of Medicine, The University of Texas Health Science Center at San Antonio, TX 78229-3900, United States.
Life Sci. 2010 Sep 25;87(13-14):391-400. doi: 10.1016/j.lfs.2010.07.010. Epub 2010 Jul 27.
The cardiac extracellular matrix (ECM) provides a platform for cells to maintain structure and function, which in turn maintains tissue function. In response to injury, the ECM undergoes remodeling that involves synthesis, incorporation, and degradation of matrix proteins, with the net outcome determined by the balance of these processes. The major goals of this review are a) to serve as an initial resource for students and investigators new to the cardiac ECM remodeling field, and b) to highlight a few of the key exciting avenues and methodologies that have recently been explored. While we focus on cardiac injury and responses of the left ventricle (LV), the mechanisms reviewed here have pathways in common with other wound healing models.
心脏细胞外基质（ECM）为细胞提供维持结构和功能的平台，进而维持组织功能。在受到损伤时，ECM 会发生重塑，包括基质蛋白的合成、掺入和降解，其净结果取决于这些过程的平衡。本综述的主要目的是：a）为刚接触心脏 ECM 重塑领域的学生和研究人员提供初步资源；b）强调最近探索的一些关键的令人兴奋的途径和方法。虽然我们重点关注心脏损伤和左心室（LV）的反应，但这里讨论的机制与其他伤口愈合模型有共同的途径。
