血清持久性有机污染物与墨西哥裔美国妇女哺乳期持续时间的关系。
Serum persistent organic pollutants and duration of lactation among Mexican-American women.
机构信息
Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA.
出版信息
J Environ Public Health. 2010;2010:861757. doi: 10.1155/2010/861757. Epub 2010 Jun 30.
BACKGROUND
Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation.
OBJECTIVES
(1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases associations.
METHODS AND RESULTS
We measured selected organochlorines and polychlorinated biphenyls (p, p'-DDE, p, p'-DDT, o, p'-DDT, beta-hexachlorocyclohexane, hexachlorobenzene, and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, Mexican-American pregnant women living in an agricultural region of California and assessed breastfeeding duration by questionnaires. We found no association between DDE, DDT, or estrogenic POPs with shortened lactation duration, but rather associations for two potentially estrogenic POPs with lengthened lactation duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p, p'-DDE & 0.8 [0.6, 1.0] for PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and shortened lactation duration were attributed to a lactation history bias.
CONCLUSION
Estrogenic POPs were not associated with shortened lactation duration, but may be associated with longer lactation duration.
背景
研究表明，雌激素类内分泌干扰化学物质会干扰哺乳。
目的
（1）确定雌激素类持久性有机污染物（POPs）是否与哺乳期缩短有关；（2）确定以前的母乳喂养史是否会影响关联。
方法和结果
我们测量了 366 名生活在加利福尼亚农业区的低收入墨西哥裔美国孕妇血清中的选定有机氯和多氯联苯（p,p'-DDE、p,p'-DDT、o,p'-DDT、β-六氯环己烷、六氯苯和 PCB44、49、52、118、138、153 和 180），并通过问卷调查评估母乳喂养持续时间。我们没有发现 DDE、DDT 或雌激素类 POPs 与哺乳期缩短有关，而是发现两种潜在的雌激素类 POPs 与哺乳期延长有关（HR [95%CI]：0.6 [0.4, 0.8] 对于 p,p'-DDE 和 0.8 [0.6, 1.0] 对于 PCB52）。抗雌激素 POPs（PCB138 和 180）与哺乳期缩短之间的关联归因于母乳喂养史的偏差。
结论
雌激素类 POPs 与哺乳期缩短无关，但可能与哺乳期延长有关。
Zotero 插件