辅因子数据库：酶催化中的有机辅因子。
The CoFactor database: organic cofactors in enzyme catalysis.
机构信息
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
出版信息
Bioinformatics. 2010 Oct 1;26(19):2496-7. doi: 10.1093/bioinformatics/btq442. Epub 2010 Aug 2.
MOTIVATION
Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database.
RESULTS
CoFactor provides a web interface to access hand-curated data extracted from the literature on organic enzyme cofactors in biocatalysis, as well as automatically collected information. CoFactor includes information on the conformational and solvent accessibility variation of the enzyme-bound cofactors, as well as mechanistic and structural information about the hosting enzymes.
AVAILABILITY
The database is publicly available and can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/CoFactor.
动机
有机酶辅因子参与许多酶反应。因此，分析辅因子对于更好地理解酶催化至关重要。为此，我们创建了 CoFactor 数据库。
结果
CoFactor 提供了一个 Web 界面，可访问从生物催化中有机酶辅因子的文献中提取的经过人工精心编辑的数据，以及自动收集的信息。CoFactor 包括有关酶结合辅因子构象和溶剂可及性变化的信息，以及有关宿主酶的机制和结构信息。
可用性
该数据库可公开获取，可通过以下网址访问：http://www.ebi.ac.uk/thornton-srv/databases/CoFactor。
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