Potter D E, Burke J A
Curr Eye Res. 1982;2(5):281-8. doi: 10.3109/02713688209000771.
The ergoline derivatives, bromocriptine, lergotrile and pergolide, are potent dopaminergic agonists. Topically administered doses of lergotrile and pergolide, ranging from 0.001 to 1% applied unilaterally, produced dose and time-related ocular hypotension in rabbits and monkeys. In contrast, bromocriptine produced moderate ocular hypotension in rabbits but not in monkeys. Lergotrile (1%) produced significant mydriasis in rabbits whereas pergolide (0.01 to 0.1%) produced a slight miosis. Lergotrile and pergolide were also effective in suppressing ocular hypertension induced by water loading in rabbits whereas bromocriptine was relatively ineffective. These data demonstrate that topically administered ergoline derivatives can: 1) lower intraocular pressure in rabbits and monkeys, 2) suppress ocular hypertension induced by water loading in rabbits and 3) alter iris function in rabbits, producing either mydriasis or miosis, presumably by activation of adrenoceptors.
麦角林衍生物溴隐亭、麦角腈和培高利特是强效多巴胺能激动剂。局部给予麦角腈和培高利特，单侧应用剂量范围为0.001%至1%，可在兔和猴身上产生与剂量和时间相关的眼压降低。相比之下，溴隐亭在兔身上可产生中度眼压降低，但在猴身上则无此作用。麦角腈（1%）在兔身上可产生显著的瞳孔散大，而培高利特（0.01%至0.1%）可产生轻微的瞳孔缩小。麦角腈和培高利特在抑制兔水负荷诱导的高眼压方面也有效，而溴隐亭相对无效。这些数据表明，局部给予麦角林衍生物可：1）降低兔和猴的眼压；2）抑制兔水负荷诱导的高眼压；3）改变兔的虹膜功能，产生瞳孔散大或缩小，推测是通过激活肾上腺素能受体实现的。
