Center of Experimental Surgery, Foundation of Biomedical Research, Academy of Athens, Athens, Greece.
Anticancer Res. 2010 Jul;30(7):2891-6.
To study the potent efficacy of the immunomodulatory agent imiquimod when applied on dysplastic lesions of the oral mucosa.
Carcinogen (DMBA) was applied to the mucosa of the left buccal pouch of 26 male Wistar rats for 8 weeks, until dysplastic lesions were observed and histologically diagnosed. At the second phase of the experiment, 5% imiquimod cream was applied to these dysplastic lesions for 16 weeks. Biopsies were taken before and after treatment.
The histological effect of imiquimod was the regression of mild dysplasia to hyperplasia for all the samples. In one case, a well-differentiated squamous cell carcinoma was converted to a papilloma-like squamous neoplasm with a benign morphology.
Our results indicate that imiquimod may be effective in treatment of precancerous lesions of the oral mucosa and thus inhibit the progress of carcinogenesis.
研究免疫调节剂咪喹莫特在口腔黏膜发育不良病变中的有效作用。
将致癌剂（DMBA）应用于 26 只雄性 Wistar 大鼠左侧颊囊黏膜 8 周，直到观察到并组织学诊断为发育不良病变。在实验的第二阶段，将 5%咪喹莫特乳膏应用于这些发育不良病变 16 周。在治疗前后进行活检。
咪喹莫特的组织学作用是所有样本中轻度发育不良向增生的消退。在一个病例中，一个分化良好的鳞状细胞癌转化为具有良性形态的乳头状鳞状新生物。
我们的结果表明，咪喹莫特可能对口腔黏膜的癌前病变有效，从而抑制癌变的进展。
