Kasr El Aini, Faculty of Medicine, Cairo University, Cairo, Egypt.
Subst Abus. 2010 Jul;31(3):162-9. doi: 10.1080/08897077.2010.495311.
The aim of the study was to investigate the effect of depression on pattern of substance use disorders (SUDs). Consecutive samples of (200) Egyptian male SUD inpatients were examined over 1-year period. Study and control samples were chosen. Study group consisted of 30 patients with comorbid substance dependence and depression. Control group consisted of 30 substance-dependent patients without depression. Semistructured interviews, Addiction Severity Index (ASI) and Hamilton Rating Scale for Depression (HDRS), were applied. Comparison between both groups showed significant differences for prescribed opioid use (100% versus 86%), polysubstance use (73% versus 43%), frequency of suicidal attempts (86% versus 43%), mean of admissions to substance use treatment (SUT) units (5 versus 2.2), mean of abstinence periods (3.8 versus 1.2); study group showed greater medical status impairment (P = .05), social and psychiatric impairment (P = .01). It was concluded that depression might affect SUD as regards type of substance used, pattern of use, suicide rate, duration of hospitalization, rate of rehospitalization, and finally medical, social, and psychiatric status impairment.
这项研究的目的是调查抑郁对物质使用障碍（SUD）模式的影响。在一年的时间里，对（200）名埃及男性 SUD 住院患者进行了连续样本检查。选择了研究组和对照组。研究组由 30 名伴有物质依赖和抑郁的患者组成。对照组由 30 名无抑郁的物质依赖患者组成。采用半结构式访谈、成瘾严重程度指数（ASI）和汉密尔顿抑郁量表（HDRS）进行评估。两组之间的比较显示，在规定的阿片类药物使用（100%对 86%）、多物质使用（73%对 43%）、自杀企图频率（86%对 43%）、物质使用治疗（SUT）单位入院次数（5 对 2.2）和禁欲期（3.8 对 1.2）方面存在显著差异；研究组的医疗状况损害更大（P=0.05），社会和精神损害更大（P=0.01）。结论是，抑郁可能会影响 SUD，包括使用的物质类型、使用模式、自杀率、住院时间、再住院率以及最终的医疗、社会和精神状态损害。
