Lee Choong Bum, Ha U-Syn, Yim Seung Hyuk, Lee Hyun Rim, Sohn Dong Wan, Han Chang Hee, Cho Yong-Hyun
The Catholic University of Korea College of Medicine, Department of Urology, St Vincent Hospital, Suwon, Korea.
Urol Int. 2011;86(2):204-9. doi: 10.1159/000320109. Epub 2011 Jan 26.
To evaluate the preventive effect of finasteride on chronic bacterial prostatitis (CBP), Wistar rats were divided into four groups: control, ciprofloxacin, finasteride, and ciprofloxacin/finasteride.
All drug pretreatments were conducted for 4 weeks, and then experimental CBP was induced by instillation of a bacterial suspension (Escherichia coli Z17 O2:K1;H-).
After 4 weeks, results of microbiological cultures of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Finasteride significantly reduced bacterial infection and decreased inflammatory cell infiltration in prostatic tissue compared with the control group. The group given both finasteride and antibiotic showed a greater inhibition of bacterial infection in the tissue than those given either finasteride or antibiotic alone.
Our experiments suggest the possibility that finasteride has a preventive effect on development of CBP, although there is as yet no consensus on the mechanism of this effect.
为评估非那雄胺对慢性细菌性前列腺炎（CBP）的预防作用，将Wistar大鼠分为四组：对照组、环丙沙星组、非那雄胺组以及环丙沙星/非那雄胺组。
所有药物预处理均进行4周，然后通过滴注细菌悬液（大肠杆菌Z17 O2:K1;H-）诱导实验性CBP。
4周后，分析了每组前列腺和尿液样本的微生物培养结果以及前列腺的组织学发现。与对照组相比，非那雄胺显著降低了细菌感染，并减少了前列腺组织中的炎性细胞浸润。同时给予非那雄胺和抗生素的组对组织中细菌感染的抑制作用比单独给予非那雄胺或抗生素的组更强。
我们的实验表明非那雄胺对CBP的发生具有预防作用，尽管目前对这种作用的机制尚未达成共识。
