Department of Public Health, Erasmus MC - University Medical Centre Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Vaccine. 2010 Sep 24;28(41):6692-7. doi: 10.1016/j.vaccine.2010.08.001. Epub 2010 Aug 12.
A discrete choice experiment was developed to investigate if girls aged 12-16 years make trade-offs between various aspects of human papillomavirus (HPV) vaccination, and to elicit the relative weight that girls' place on these characteristics. Degree of protection against cervical cancer, protection duration, risk of side-effects, and age of vaccination, all proved to influence girls' preferences for HPV vaccination. We found that girls were willing to trade-off 38% protection against cervical cancer to obtain a lifetime protection instead of a protection duration of 6 years, or 17% to obtain an HPV vaccination with a 1 per 750,000 instead of 1 per 150,000 risk of serious side-effects. We conclude that girls indeed made a trade-off between degree of protection and other vaccine characteristics, and that uptake of HPV vaccination may change considerably if girls are supplied with new evidence-based information about the degree of protection against cervical cancer, the protection duration, and the risk of serious side-effects.
一项离散选择实验表明，12-16 岁的女孩会在人乳头瘤病毒（HPV）疫苗的各个方面进行权衡取舍，并评估她们对这些特征的相对重视程度。预防宫颈癌的程度、保护持续时间、副作用风险和接种年龄均会影响女孩对 HPV 疫苗的偏好。我们发现，女孩愿意用 38%的宫颈癌预防效果换取终生保护，而不是 6 年的保护期，或者用 17%的宫颈癌预防效果换取 HPV 疫苗，该疫苗的严重副作用风险为每 75 万分之一，而不是每 15 万分之一。我们得出结论，女孩确实在预防效果的程度和其他疫苗特征之间进行了权衡取舍，如果向女孩提供有关预防宫颈癌的程度、保护持续时间和严重副作用风险的新循证信息，HPV 疫苗的接种率可能会发生很大变化。
