Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity.
作者信息
McCormick Thomas S, Weinberg Aaron
出版信息
Periodontol 2000. 2010 Oct;54(1):195-206. doi: 10.1111/j.1600-0757.2010.00373.x.
Abstract
摘要
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The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells.促炎肽LL-37通过募集多能间充质基质细胞促进卵巢肿瘤进展。
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3806-11. doi: 10.1073/pnas.0900244106. Epub 2009 Feb 20.
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Overexpression of human beta-defensin-3 in oral dysplasia: potential role in macrophage trafficking.人β-防御素-3 在口腔发育不良中的过表达：在巨噬细胞迁移中的潜在作用。
Oral Oncol. 2009 Aug;45(8):696-702. doi: 10.1016/j.oraloncology.2008.10.016. Epub 2008 Dec 18.
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Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas.从胰腺中分离出一种结晶状的胰蛋白酶抑制剂-抗凝血蛋白。
J Am Chem Soc. 1948 Sep;70(9):3034-40. doi: 10.1021/ja01189a060.
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Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways.宿主防御肽LL-37与炎症介质IL-1β协同作用，通过多种途径增强免疫反应。
J Immunol. 2007 Dec 1;179(11):7684-91. doi: 10.4049/jimmunol.179.11.7684.
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Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.人防御素-3通过Toll样受体1和2激活专职抗原呈递细胞。
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18631-5. doi: 10.1073/pnas.0702130104. Epub 2007 Nov 15.
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In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37.人源抗菌肽LL-37在体外和体内促进伤口愈合的活性
J Invest Dermatol. 2008 Jan;128(1):223-36. doi: 10.1038/sj.jid.5701043. Epub 2007 Sep 13.
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An anti-infective peptide that selectively modulates the innate immune response.一种选择性调节先天免疫反应的抗感染肽。
Nat Biotechnol. 2007 Apr;25(4):465-72. doi: 10.1038/nbt1288. Epub 2007 Mar 25.
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Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.抗菌肽人β-防御素（hBD）-3和hBD-4可激活肥大细胞并增加皮肤血管通透性。
Eur J Immunol. 2007 Feb;37(2):434-44. doi: 10.1002/eji.200636379.
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Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.抗菌肽人β-防御素可刺激表皮角质形成细胞迁移、增殖以及促炎细胞因子和趋化因子的产生。
J Invest Dermatol. 2007 Mar;127(3):594-604. doi: 10.1038/sj.jid.5700599. Epub 2006 Oct 19.
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Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.前沿：人β-防御素3——HIV-1共受体CXCR4的新型拮抗剂。
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