Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, The M. S. University of Baroda, Vadodara 390 002, Gujarat, India.
J Ethnopharmacol. 2010 Oct 28;132(1):365-7. doi: 10.1016/j.jep.2010.08.037. Epub 2010 Aug 20.
Sida rhomboidea.Roxb (SR) known as "Mahabala" in Ayurveda and marketed as "Shahadeyi" is used in ethnomedicine to treat ailments such as dysuria and urinary disorders.
To evaluate nephroprotective potential of SR against gentamicin (GM) induced nephrotoxicity and renal dysfunction.
Nephrotoxicity was induced in rats with GM (100 mg/kg bodyweight (i.p.) for 8 days) and were treated with SR extract (200 and 400 mg/kg bodyweight (p.o.) for 8 days) or 0.5% carboxymethyl cellulose (vehicle). Plasma and urine urea and creatinine, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated in various experimental groups.
GM treatment induced significant elevation (p<0.05) in plasma and urine urea, creatinine, renal lipid peroxidation along with significant decrement (p<0.05) in renal enzymatic and non-enzymatic antioxidants. SR treatment to GM treated rats (GM+SR) recorded significant decrement (p<0.05) in plasma and urine urea and creatinine, renal lipid peroxidation along with significant increment (p<0.05) in renal enzymatic and non-enzymatic antioxidants.
SR leaf extract ameliorates GM induced nephrotoxicity and renal dysfunction and thus validates its ethnomedicinal use.
Sida rhomboidea.Roxb（SR）在印度草医学中被称为“Mahabala”，并以“Shahadeyi”的形式销售，用于治疗尿痛和泌尿系统疾病等疾病。
评估 SR 对庆大霉素（GM）诱导的肾毒性和肾功能障碍的肾保护潜力。
用 GM（100mg/kg 体重（腹腔注射），共 8 天）诱导大鼠肾毒性，并以 SR 提取物（200 和 400mg/kg 体重（口服），共 8 天）或 0.5%羧甲基纤维素（载体）治疗。在各个实验组中评估血浆和尿液尿素和肌酐、肾酶和非酶抗氧化剂以及脂质过氧化。
GM 处理诱导血浆和尿液尿素、肌酐、肾脂质过氧化显著升高（p<0.05），同时肾酶和非酶抗氧化剂显著降低（p<0.05）。SR 处理 GM 处理大鼠（GM+SR）后，血浆和尿液尿素和肌酐、肾脂质过氧化显著降低（p<0.05），同时肾酶和非酶抗氧化剂显著升高（p<0.05）。
SR 叶提取物可改善 GM 诱导的肾毒性和肾功能障碍，从而验证了其在民族医学中的应用。
