Department of Biology, University of Hartford, West Hartford, CT, 06117, USA.
Exp Gerontol. 2011 May;46(5):391-6. doi: 10.1016/j.exger.2010.08.007. Epub 2010 Aug 20.
The silent information regulator 2 (Sir2 or Sirtuin) family of proteins is highly conserved and has been implicated in the extension of longevity for several species. Mammalian Sirtuins have been shown to affect various aspects of physiology including metabolism, the stress response, cell survival, replicative senescence, inflammation, the circadian rhythm, neurodegeneration, and even cancer. Evidence in Drosophila implicates Sir2 in at least some of the beneficial effects of caloric restriction (CR). CR delays age-related pathology and extends life span in a wide variety of species. Here we will review the evidence linking Drosophila Sir2 (dSir2) to longevity regulation and the pathway associated with CR in Drosophila, as well as the effects of the Sir2 activator resveratrol and potential interactions between dSir2 and p53.
沉默信息调节因子 2（Sir2 或 Sirtuin）家族蛋白高度保守，已被牵连到多种物种寿命的延长。哺乳动物 Sirtuins 已被证明会影响包括代谢、应激反应、细胞存活、复制性衰老、炎症、昼夜节律、神经退行性变，甚至癌症在内的各种生理方面。果蝇中的证据表明 Sir2 至少与热量限制（CR）的一些有益效果有关。CR 可延缓与年龄相关的病变并延长多种物种的寿命。在这里，我们将回顾将果蝇 Sir2（dSir2）与寿命调节以及与果蝇 CR 相关的途径联系起来的证据，以及 Sir2 激活剂白藜芦醇的影响以及 dSir2 和 p53 之间的潜在相互作用。
