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酒精、四氢大麻酚及其组合对感知效果、驾驶意愿以及驾驶和非驾驶任务表现的影响。

The effect of alcohol, THC and their combination on perceived effects, willingness to drive and performance of driving and non-driving tasks.

机构信息

Ben-Gurion University of the Negev, Beer Sheva, Israel.

出版信息

Accid Anal Prev. 2010 Nov;42(6):1855-65. doi: 10.1016/j.aap.2010.05.006. Epub 2010 Jun 9.

Abstract

BACKGROUND

Driving under the influence of drugs (DUID) is one of the main causes of car accidents. Alcohol and marijuana are the most popular drugs among recreational users. Many classify these drugs as "Light" drugs and therefore allow themselves to drive after consuming them.

OBJECTIVE

The study had two main objectives: 1) to investigate the effect of alcohol (BAC=0.05%), THC (13 mg) and their combination on driving and non-driving tasks. 2) to investigate the extent to which people are willing to drive based on their subjective sensations and their perceived effects of the drugs.

METHOD

7 healthy men and 5 healthy women, ages 24-29, all recreational users of alcohol and marijuana, completed 5 experimental sessions. Sessions included: drinking and smoking placebo, drinking alcohol and smoking placebo, drinking placebo and smoking THC, drinking alcohol and smoking THC, drinking placebo and smoking placebo 24 hours after drinking alcohol and smoking THC. Three types of measures were used: subjective perceptions (with questionnaires), performance parameters of the driving and non-driving tasks (arithmetic task and a secondary target detection task) and physiological changes (heart rate).

RESULTS

Overall, the combination of alcohol and THC had the most intense effect after intake. This effect was reflected in performance impairments observed in the driving and non-driving tasks, in the subjective sensations after intake, and in the physiological measures. Despite significant differences in the size of the effects after the various treatments, there were no differences in the distances subjects were willing to drive while under the influence on each of the treatments.

摘要

背景

药物影响下驾驶(DUID)是造成车祸的主要原因之一。酒精和大麻是娱乐性使用者中最常见的毒品。许多人将这些药物归类为“轻”毒品,因此允许自己在吸食后驾驶。

目的

该研究有两个主要目的:1)调查酒精(BAC=0.05%)、THC(13 毫克)及其组合对驾驶和非驾驶任务的影响。2)调查人们根据自己的主观感觉和对药物的感知效果,愿意在多大程度上开车。

方法

7 名健康男性和 5 名健康女性,年龄在 24-29 岁之间,均为酒精和大麻的娱乐性使用者,完成了 5 次实验。这些实验包括:饮用和吸食安慰剂、饮用酒精和吸食安慰剂、饮用安慰剂和吸食 THC、饮用酒精和吸食 THC、饮用安慰剂和吸食安慰剂 24 小时后吸食酒精和吸食 THC。使用了三种类型的测量方法:主观感知(通过问卷)、驾驶和非驾驶任务的绩效参数(算术任务和次要目标检测任务)以及生理变化(心率)。

结果

总的来说,酒精和 THC 的组合在摄入后影响最强烈。这种影响反映在驾驶和非驾驶任务中的表现障碍、摄入后的主观感觉以及生理测量中。尽管在各种处理后的影响大小存在显著差异,但在每种处理下,受试者愿意在受影响的情况下驾驶的距离没有差异。

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