Department of Psychology, University of California at Los Angeles, Psychology Building 1285, Los Angeles, CA 90095, USA.
Department of Psychology, University of California at Los Angeles, Psychology Building 1285, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
Drug Alcohol Depend. 2022 Jul 1;236:109481. doi: 10.1016/j.drugalcdep.2022.109481. Epub 2022 Apr 30.
Cannabis is often used in combination with alcohol; yet, whether cannabis use impacts risk factors for alcohol use disorder (AUD) remains unknown. Subjective response (SR) to alcohol represents a biobehavioral risk factor for subsequent heavy drinking and for developing AUD. Given the high prevalence of alcohol and cannabis co-use, it is plausible to hypothesize that cannabis users differ in SR to alcohol compared to non-cannabis users. The purpose of this study is to examine the influence of past-month cannabis use on subjective response to alcohol in the human laboratory.
This study culled data from multiple alcohol administration trials to test whether cannabis users, compared to non-cannabis users, differed in subjective response to alcohol, comprised of four domains: stimulation, sedation, negative affect, and craving. Non-treatment-seeking heavy drinkers (N = 168) completed a battery of self-report scales of mood and alcohol/cigarette/cannabis use and problems. All participants completed an intravenous alcohol administration session wherein SR domains were measured at the following breath alcohol concentrations (BrAC): baseline (i.e., 0), 20, 40, and 60 mg%.
Multilevel statistical analyses revealed that cannabis users had a greater reduction in negative affect during alcohol administration, compared to non-cannabis users. No significant differences were found for the other SR domains.
Using a large sample and advanced data analytic methods, this study extends the literature by suggesting that cannabis users are more sensitive to alcohol-induced reductions in negative affect compared to non-cannabis users. This work extends research on how cannabis use may influence risk factors for AUD, such as subjective response to alcohol.
大麻常与酒精同时使用；然而，大麻的使用是否会影响酒精使用障碍（AUD）的风险因素尚不清楚。对酒精的主观反应（SR）是随后大量饮酒和 AUD 发展的生物行为风险因素。鉴于酒精和大麻共同使用的高患病率，有理由假设与非大麻使用者相比，大麻使用者对酒精的主观反应不同。本研究的目的是在人体实验室中检查过去一个月大麻使用对酒精主观反应的影响。
本研究从多次酒精给药试验中提取数据，以测试与非大麻使用者相比，大麻使用者在酒精主观反应方面是否存在差异，包括四个领域：兴奋、镇静、负性情绪和渴求。非治疗性重度饮酒者（N=168）完成了一系列关于情绪和酒精/香烟/大麻使用和问题的自我报告量表。所有参与者都完成了静脉内酒精给药阶段，在以下呼气酒精浓度（BrAC）下测量 SR 域：基线（即 0）、20、40 和 60mg%。
多层次统计分析显示，与非大麻使用者相比，大麻使用者在酒精给药期间的负性情绪降低幅度更大。其他 SR 域没有发现显著差异。
本研究使用大量样本和先进的数据分析方法，通过表明与非大麻使用者相比，大麻使用者对酒精引起的负性情绪降低更为敏感，从而扩展了文献。这项工作扩展了关于大麻使用如何影响 AUD 风险因素（如对酒精的主观反应）的研究。
