血糖控制对 2 型糖尿病患者牙周袋中 Epstein-Barr 和巨细胞病毒感染的影响。
Influence of glycemic control on Epstein-Bar and Cytomegalovirus infection in periodontal pocket of type 2 diabetic subjects.
机构信息
Department of Prosthodontics and Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
出版信息
Arch Oral Biol. 2010 Nov;55(11):902-6. doi: 10.1016/j.archoralbio.2010.07.009. Epub 2010 Aug 21.
OBJECTIVE
The aim of the present study was to evaluate the influence of glycemic control on the frequency of Epstein-Bar (EBV) and Cytomegalovirus (CMV) in periodontal pockets of type 2 diabetic subjects with chronic periodontitis.
DESIGN
Forty-six subjects presenting generalized chronic periodontitis and type 2 diabetes mellitus (DM) were selected for this study. Polymerase chain reaction (PCR) was used to determine the presence of EBV and CMV in shallow [Probing Depth (PD)≤3mm], moderate (PD=4-6mm) and deep (PD>7mm) pockets. HbA1c levels ≤7%, >7 to <10%, and ≥10% defined good, moderate and poor glycemic control, respectively.
RESULTS
Higher frequency of EBV was found in the shallow pockets of the subjects with poor glycemic control (p<0.05; chi-square test). Moreover, EBV-free subjects presented moderate or good glycemic control. Glycemic control did not influence the frequency of CMV in all pocket categories.
CONCLUSION
Poor glycemic control in type 2 diabetic subjects can increase the occurrence of EBV in shallow periodontal pockets.
目的
本研究旨在评估血糖控制对伴有慢性牙周炎的 2 型糖尿病患者牙周袋中 EBV（Epstein-Bar）和 CMV（Cytomegalovirus）频率的影响。
设计
本研究选择了 46 名患有广泛性慢性牙周炎和 2 型糖尿病（DM）的受试者。聚合酶链反应（PCR）用于确定 EBV 和 CMV 在浅（探诊深度[PD]≤3mm）、中（PD=4-6mm）和深（PD>7mm）牙周袋中的存在情况。HbA1c 水平分别定义为≤7%、>7 至<10%和≥10%的良好、中度和差血糖控制。
结果
在血糖控制不佳的受试者的浅牙周袋中发现 EBV 频率更高（p<0.05；卡方检验）。此外，无 EBV 的受试者血糖控制处于中度或良好状态。血糖控制对所有牙周袋类别中 CMV 的频率没有影响。
结论
2 型糖尿病患者血糖控制不佳可能会增加 EBV 在浅牙周袋中的发生。
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