全谷物制品的摄入与 Diet, Cancer and Health 队列研究中结直肠癌风险的关系。
Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.
机构信息
Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark.
出版信息
Br J Cancer. 2010 Aug 24;103(5):730-4. doi: 10.1038/sj.bjc.6605806.
BACKGROUND
Consumption of wholegrain (WG) products may protect against colon and rectal cancer.
METHODS
The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal cancer that developed during 10.6 years (median) of follow-up among 26 630 men and 29 189 women taking part in the Diet, Cancer and Health cohort. Incidence rate ratios (IRRs) of colon and rectal cancer related to total or individual WG product intake were calculated using Cox regression.
RESULTS
Higher WG product intake was associated with lower risk of colon cancer and rectal cancer in men. The adjusted IRR (95% CI) was 0.85 (0.77-0.94) for colon cancer and 0.90 (0.80-1.01) for rectal cancer per daily 50 g increment in intake. For colon cancer the association was confined to intake of WG bread in particular. No consistent associations between total or individual WG product consumption and colon or rectal cancer risk were observed in women.
CONCLUSION
The findings suggest that higher total WG product intake is associated with a lower risk of colon and perhaps rectal cancer in men, but not in women.
背景
全谷物（WG）产品的消费可能有助于预防结肠癌和直肠癌。
方法
利用参加饮食、癌症与健康队列研究的 26630 名男性和 29189 名女性在 10.6 年（中位数）的随访期间新发的 461 例结肠癌和 283 例直肠癌病例的数据，前瞻性地检查了总 WG 产品和个体 WG 产品消费与结肠癌和直肠癌风险之间的关系。采用 Cox 回归计算总 WG 产品或个体 WG 产品摄入与结肠癌和直肠癌相关的发病率比（IRR）。
结果
更高的 WG 产品摄入与男性结肠癌和直肠癌风险降低相关。调整后的 IRR（95%CI）为，摄入每增加 50 克，结肠癌风险降低 0.85（0.77-0.94），直肠癌风险降低 0.90（0.80-1.01）。对于结肠癌，这种关联仅限于 WG 面包的摄入。在女性中，总 WG 产品或个体 WG 产品的摄入与结肠癌或直肠癌风险之间没有一致的关联。
结论
研究结果表明，男性总 WG 产品摄入较高与结肠癌和（或许）直肠癌风险降低相关，但女性则不然。
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