维特吲哚啉酮C的合成研究。通过跨环硝酮环加成构建维特吲哚啉酮碳骨架。
Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition.
作者信息
Freeman David B, Holubec Alexandra A, Weiss Matthew W, Dixon Julie A, Kakefuda Akio, Ohtsuka Masami, Inoue Munenori, Vaswani Rishi G, Ohki Hidenori, Doan Brian D, Reisman Sarah E, Stoltz Brian M, Day Joshua J, Tao Ran N, Dieterich Noah A, Wood John L
机构信息
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Tetrahedron. 2010 Aug 14;66(33):6647-6655. doi: 10.1016/j.tet.2010.04.131.
Abstract
Described is the construction of the N-methylwelwitindolinone C core via an efficient strategy that employs a sequential rhodium carbenoid-mediated O-H insertion, Claisen rearrangement and transannular [3+2] nitrone cycloaddition.
摘要
描述了通过一种高效策略构建N-甲基welwitindolinone C核，该策略采用了铑卡宾介导的顺序O-H插入、克莱森重排和跨环[3+2]硝酮环加成反应。
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