Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charité - Universitätsmedizin, Berlin, Germany.
Br J Nutr. 2011 Jan;105(2):263-7. doi: 10.1017/S0007114510003284. Epub 2010 Aug 24.
Epidemiological studies suggest that consumption of tomato products reduces the risk of CVD via antioxidant, hypocholesterolaemic and anti-inflammatory mechanisms. Although experimental data also describe beneficial effects on endothelial function, clinical data in human subjects are lacking. To test the hypothesis that tomato ingestion ameliorates endothelial function, we randomised healthy non-smoking postmenopausal women to consume a buttered roll with and without tomato purée (70 g) in a cross-over design. Endothelial-dependent flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation of the brachial artery were assessed with high-resolution ultrasound (13 MHz linear array transducer). Acute (24 h) and long-term (7 d) effects were examined after daily consumption of the described meal. Nineteen volunteers completed the protocol and provided technically suitable ultrasound measurement data. Plasma lycopene levels increased from 0·30 (sem 0·04) (baseline) to 0·42 (sem 0·04) and to 0·74 (sem 0·06) μm after 24 h and 7 d, respectively, with tomato purée consumption. These data indicated an effective absorption of the tomato product. However, both acute and long-term tomato purée consumption had no effects on endothelium-dependent or -independent dilation of the brachial artery. In addition, we found no correlation between lycopene plasma levels and FMD. In conclusion, consumption of tomato products associated with a significant increase in plasma lycopene levels had no effects on endothelial function in healthy postmenopausal women.
流行病学研究表明，食用番茄制品通过抗氧化、降胆固醇和抗炎机制降低 CVD 的风险。尽管实验数据也描述了对内皮功能的有益影响，但人体临床数据缺乏。为了验证摄入番茄可以改善内皮功能的假设，我们采用交叉设计，将健康不吸烟的绝经后妇女随机分为两组，分别食用涂有番茄泥和无番茄泥的黄油面包（70g）。采用高分辨率超声（13MHz 线性阵列换能器）评估肱动脉内皮依赖性血流介导的舒张功能（FMD）和内皮非依赖性硝普盐介导的舒张功能。在每日食用所述膳食后，分别检测急性（24 小时）和长期（7 天）的影响。19 名志愿者完成了该方案，并提供了技术上合适的超声测量数据。血浆番茄红素水平分别从 0.30（sem 0.04）（基线）增加到 0.42（sem 0.04）和 0.74（sem 0.06）μm，分别在食用番茄泥 24 小时和 7 天后。这些数据表明番茄制品被有效吸收。然而，急性和长期食用番茄泥均对肱动脉的内皮依赖性或非依赖性舒张无影响。此外，我们发现番茄红素的血浆水平与 FMD 之间没有相关性。总之，食用与血浆番茄红素水平显著增加相关的番茄制品对健康绝经后妇女的内皮功能没有影响。
