Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, 114 Vasilisis Sofias Ave, Athens, Greece.
Nutr Res. 2012 May;32(5):390-4. doi: 10.1016/j.nutres.2012.03.011. Epub 2012 May 15.
Consumption of tomato products is linked to beneficial outcomes through antioxidant and anti-inflammatory mechanisms. The aim of this study was to determine whether a 14-day period of tomato paste supplementation would improve endothelial function. Nineteen volunteers (mean age, 39 ± 13 years; 8 men/11 women) were studied in a randomized (exposure sequence), single-blind (operator), crossover design. The study consisted of a supplementation arm (70 g tomato paste containing 33.3 mg of lycopene) and a control arm, during which no tomato paste was added to their regular diet. Volunteers maintained their regular diet during study arms. Two-week washout periods preceded each arm. Flow-mediated dilatation (FMD) measured by brachial artery ultrasonography was used as an estimate of endothelial function at day 1 (acute response) and day 15 (midterm response). Plasma lipid peroxides were measured with a photometric enzyme-linked immunosorbent assay as an index of total oxidative status. Tomato supplementation led to an overall FMD increase compared with the control period (P = .047 for repeated-measures 3 × 2 analysis of variance). At day 1, FMD was not significantly increased (P = .329). By day 15, tomato supplementation resulted in an increase in FMD by 3.3% ± 1.4%, whereas at the control arm, FMD declined by -0.5% ± 0.6% (P = .03); magnitudes of change are absolute FMD values. Total oxidative status decreased at the end of the supplementation period compared with baseline values (P = .038). Daily tomato paste consumption exerts a beneficial midterm but not short-term effect on endothelial function. Further studies are warranted to explore the effects of tomato paste on endothelial dilation in different age groups and comorbidities.
食用番茄制品通过抗氧化和抗炎机制与有益结果相关联。本研究旨在确定 14 天的番茄酱补充是否会改善内皮功能。19 名志愿者（平均年龄，39 ± 13 岁；8 男/11 女）按随机（暴露顺序）、单盲（操作者）、交叉设计进行研究。该研究包括补充组（含有 33.3 毫克番茄红素的 70 克番茄酱）和对照组，在对照组中，他们的日常饮食中不添加番茄酱。志愿者在研究期间保持常规饮食。在每个手臂之前进行两周的洗脱期。肱动脉超声测量的血流介导的扩张（FMD）作为内皮功能的估计在第 1 天（急性反应）和第 15 天（中期反应）进行测量。用分光光度酶联免疫吸附测定法测量血浆脂质过氧化物作为总氧化状态的指标。与对照组相比，番茄补充剂导致 FMD 总体增加（重复测量 3 × 2 方差分析，P =.047）。第 1 天，FMD 没有显著增加（P =.329）。到第 15 天，番茄补充剂使 FMD 增加了 3.3%±1.4%，而对照组 FMD 下降了-0.5%±0.6%（P =.03）；变化幅度是绝对 FMD 值。与基线值相比，补充期结束时总氧化状态降低（P =.038）。番茄汁的日常食用对内皮功能有中期的有益影响，但没有短期影响。需要进一步研究以探索番茄酱对不同年龄组和合并症的内皮扩张的影响。
